High-protein delivery in mechanically ventilated patients: A study protocol for a randomized trial

Background: Critically ill patients are at risk of malnutrition; thus, optimal nutrition delivery is a key treatment for better outcomes. Inadequate energy and protein intake increase rate hospital-acquired infection, duration mechanical ventilation mortality. However, there no clear consensus regarding dose in mechanically ventilated patients. In this study, we aim to compare between the effect high usual on clinical outcomes patient group. Methods: This single-centered, open-labelled, parallel-group, randomized controlled study conducting medical, surgical trauma intensive care units (ICU) tertiary university hospital Bangkok, Thailand. We plan enroll 240 adult who expected require ventilator support least 3 days. The intervention group will be prescribed (at 1.5 g/kg/day) throughout ICU stay since day 4 until maximum 28 days, whereas control (1-1.3 g/kg/day). Nutrition provided by enteral or parenteral route both. primary outcome ventilator-free days main secondary include temporal change muscle mass SOFA score, nosocomial infection 28-day Conclusion: robust evidence whether delivering critically improves lacking. trial examine consequence population.